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N-ethyl Nitrazepam
Item number: Cay41870-1
An analytical reference standard categorized as a benzodiazepine, intended for research and forensic applications. Formulation: A solid. InChI: InChI=1S/C17H15N3O3/c1-2-19-15-9-8-13(20(22)23)10-14(15)17(18-11-16(19)21)12-6-4-3-5-7-12/h3-10H,2,11H2,1H3. InChIKey: PAUVQVSWHYRFRY-UHFFFAOYSA-N. SMILES:...
| Keywords: | 1-ethyl-1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one |
| Application: | Analytical reference standard, benzodiazepine |
| CAS | 124862-95-9 |
| MW: | 309.32 D |
From 101.00€
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YH-306
Item number: Cay41874-10
An anticancer agent, reduces TGF-beta-induced transcriptional activity by 72.4% in a reporter assay using HaCaT cells at 1 µM, inhibits the proliferation of PC-9, H1299, and A549 cells (IC50s = 5.87, 8.07, and 7.9 µM, respectively), decreases migration of H1299 cells in a wound healing assay at 0.1, 0.5, or 1 µM,...
| Keywords: | 2-(4-hydroxyphenyl)-1-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-ethanone |
| Application: | Anticancer agent |
| CAS | 1373764-75-0 |
| MW: | 306.4 D |
From 85.00€
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SQ-609
Item number: Cay41875-10
An antibacterial agent, reduces the proliferation of M. tuberculosis in M. tuberculosis-infected J774 macrophages (MIC = 4 µg/ml), increases survival time in M. tuberculosis-infected female mice at 10 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | 1-[[1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-4-piperidinyl]methyl]-4-piperidinol |
| Application: | Antibacterial agent |
| CAS | 627052-25-9 |
| MW: | 346.6 D |
From 76.00€
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ISRIB
Item number: Cay41879-10
A mixture of cis-IRIB and trans-ISRIB, trans-ISRIB decreases ATF4-induced increases in gene transcription more effectively than cis-ISRIB in a reporter assay using HEK293T cells (IC50s = 5 and 600 nM, respectively), trans-ISRIB decreases the latency to escape in the Morris water maze and increases the length of...
| Keywords: | N,N'-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide |
| Application: | Cis-IRIB / trans-ISRIB mixture |
| CAS | 548470-11-7 |
| MW: | 451.3 D |
From 76.00€
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Macimorelin (acetate)
Item number: Cay41886-10
A growth hormone secretagogue and ghrelin receptor agonist, binds to GHS-R1a (IC50 = 123 nM for the human receptor), oral administration increases plasma growth hormone levels in dogs at 1 mg/kg, decreases gastric acid secretion in pylorus-ligated rats at 0.01 or 1 nmol/animal, i.c.v., increases acute food intake...
| Keywords: | AEZS-130, Aib-D-Trp-D-gTrp-CHO, Aib-D-Trp-D-gTrp-formyl, D 87575, EP 1572, JMV1843,... |
| Application: | Growth hormone secretagogue, ghrelin receptor agonist |
| CAS | 945212-59-9 |
| MW: | 534.61 D |
From 223.00€
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Dihydroartemisinin (mixed isomers)
Item number: Cay41908-1
A mixture of dihydroartemisinin isomers, contains alpha-dihydroartemisinin and beta-dihydroartemisinin. Formulation: A crystalline solid. InChI: InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1. InChIKey:...
| Keywords: | (3R,5aS,6R,8aS,9R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol |
| Application: | Dihydroartemisinin isomers mixture |
| CAS | 131175-87-6 |
| MW: | 284.4 D |
From 153.00€
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CP-LC-1428
Item number: Cay41924-10
Lipid CP-LC-1428 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG:...
| Keywords: | 6-methylheptyl... |
| Application: | Ionizable cationic amino lipid, homocysteine derivative |
| MW: | 1004.58 D |
From 229.00€
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Lipid 12T-O14
Item number: Cay41946-1
An amidine-incorporated degradable lipid (pKa 8.15), has been used in the generation of LNPs for the delivery of siRNA and mRNA in vitro or in vivo, LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells, intramuscular delivery of LNPs containing lipid 12T-O14 and...
| Keywords: | tetradecyl 3-((4-((4-decylphenyl)amino)-4-iminobutyl)thio)propanoate |
| Application: | Amidine-incorporated degradable lipid, LNP formation |
| MW: | 603 D |
From 116.00€
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CM-4620
Item number: Cay41977-10
An inhibitor of Orai1/STIM1-containing SOCs (IC50 = 120 nM), selective for Orai1/STIM1-containing SOCs over Orai2/STIM2-containing SOCs (IC50 = 900 nM), decreases cholecystokinin- or taurolithocholic acid 3-sulfate-induced cell death in isolated mouse, rat, and human acini at 3 µM, reduces blood amylase and lipase...
| Keywords: | Zegrocractin, N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methyl-benzamide |
| Application: | Orai1/STIM1-containing SOC (store-operated calcium channel) inhibitor |
| CAS | 1713240-67-5 |
| MW: | 421.8 D |
From 116.00€
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AZD 4320
Item number: Cay41978-1
An inhibitor of the Bcl-2-Bim and Bcl-xL-Bim protein-protein interactions (IC50s = 3.9 and 4.5 nM, respectively, in fluorescence polarization assays), induces apoptosis in MLL-AF9,NrasG12D mouse AML cells overexpressing human Bcl-2 or Bcl-xL but not Mcl-1, Bfl-1, or Bcl-W at 1 µM, induces apoptosis in wild-type but...
| Keywords: | 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(ph... |
| Application: | Bcl-2-Bim / Bcl-xL-Bim protein-protein interactions inhibitor |
| CAS | 1357576-48-7 |
| MW: | 945.5 D |
From 60.00€
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GSK1482160
Item number: Cay41980-10
A P2X7 receptor antagonist (IC50 = 3.2 nM for the human receptor), inhibits LPS- and BzATP-induced increases in ROS levels in THP-1 macrophages at 1 µM, decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human...
| Keywords: | (2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxo-2-pyrrolidinecarboxamide |
| Application: | P2X7 receptor antagonist |
| CAS | 1001389-72-5 |
| MW: | 334.72 D |
From 120.00€
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DFSX-2
Item number: Cay41981-1
A precursor in the synthesis of delafloxacin. Formulation: A solid. InChI: InChI=1S/C24H23F3N4O5/c1-4-35-24(34)14-10-31(22-17(27)6-16(26)21(28)29-22)18-7-19(15(25)5-13(18)20(14)32)30-8-12(9-30)36-23(33)11(2)3/h5-7,10-12H,4,8-9H2,1-3H3,(H2,28,29). InChIKey: VMXLACIKUJJQTC-UHFFFAOYSA-N. SMILES:...
| Keywords: | 1-(6-amino-3,5-difluoro-2-pyridinyl)-6-fluoro-1,4-dihydro-7-[3-(2-methyl-1-oxopropoxy)-1-azetidinyl]-4-oxo-3-quinolinecarb... |
| Application: | Delafloxacin synthesis precursor |
| CAS | 442526-91-2 |
| MW: | 504.46 D |
From 70.00€
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