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Spongosine
Item number: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Keywords: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Application: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
From 76.00€
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MMV390048
Item number: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Keywords: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Application: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
From 107.00€
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AQW-051
Item number: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Keywords: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Application: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
From 104.00€
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GSK3685032
Item number: Cay41882-1
A DNMT1 inhibitor (IC50 = 0.23 µM), selective for DNMT1 over DNMT3A/3L and DNMT3B/3L and a panel of 34 methyltransferases and 369 kinases (IC50s = >10 µM for all), inhibits the proliferation of 51 hematological cancer cell lines (median IC50 = 0.64 µM), decreases overall DNA methylation and gene expression in...
| Keywords: | aR-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-benzeneacetamide |
| Application: | DNMT1 inhibitor |
| CAS | 2170140-50-6 |
| MW: | 420.54 D |
From 104.00€
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Santalol
Item number: Cay41891-100
A mixture of alpha-santalol and beta-santalol. Formulation: A neat oil. InChI: InChI=1S/2C15H24O/c1-10(9-16)5-4-6-14(2)11-7-12-13(8-11)15(12,14)3,1-11(10-16)5-4-8-15(3)12(2)13-6-7-14(15)9-13/h5,11-13,16H,4,6-9H2,1-3H3,5,13-14,16H,2,4,6-10H2,1,3H3/b10-5-,11-5-/t11?,12-,13?,14+,15?,13-,14+,15+/m01/s1. InChIKey:...
| Application: | Sesquiterpenoids, alpha-santalol/beta-santalol mixture |
| CAS | 11031-45-1 |
| MW: | 220.4 D |
From 45.00€
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BH400
Item number: Cay41892-1
A PPARalpha agonist and STING inhibitor (IC50 = 8.1 µM), induces transactivation of PPARalpha in a reporter assay using THP-1 cells (EC50 = 1.2 µM), inhibits 4-HNE- or H2O2-induced decreases in viability in 661W cells at 10 µM, prevents LPS-induced increases in phosphorylated TBK1 and IL-6 levels and LPS-induced...
| Keywords: | 5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid |
| Application: | PPARalpha agonist, STING inhibitor |
| MW: | 337.4 D |
From 116.00€
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DBCO acid
Item number: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Keywords: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Application: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
From 43.00€
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4-Amino-D-phenylalanine
Item number: Cay41971-1
A synthetic amino acid and building block, has been used in the synthesis of CXCR4 antagonists. Formulation: A solid. InChI: InChI=1S/C9H12N2O2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,10-11H2,(H,12,13)/t8-/m1/s1. InChIKey: CMUHFUGDYMFHEI-MRVPVSSYSA-N. SMILES: OC([C@H](N)CC1=CC=C(C=C1)N)=O
| Keywords: | 4-NH2-D-Phe, p-Amino-D-phenylalanine, para-Amino-D-phenylalanine, (R)-2-amino-3-(4-aminophenyl)propanoic acid |
| Application: | Synthetic amino acid, building block |
| CAS | 102281-45-8 |
| MW: | 180.2 D |
From 132.00€
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EM-12-FS
Item number: Cay41983-10
An NTAQ1 degrader, binds to CRBN (IC50 = 256 nM) and covalently labels His353, reduces the levels of NTAQ1 in MOLT-4 cells in a NEDDylation-dependent manner at 1 and 5 µM. Formulation: A solid. InChI:...
| Keywords: | 3-[6-[(fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione |
| Application: | NTAQ1 degrader |
| CAS | 2839138-44-0 |
| MW: | 342.3 D |
From 137.00€
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KDS-0071
Item number: Cay41996-10
An imidazole-containing compound. Formulation: A solid. InChI: InChI=1S/C22H23FN4O3S/c23-18-12-16(6-7-17(18)13-26-8-10-31(29,30)11-9-26)19-2-1-3-21-24-20(14-27(19)21)25-22(28)15-4-5-15/h1-3,6-7,12,14-15H,4-5,8-11,13H2,(H,25,28). InChIKey: QDYVZZJCRDVVQG-UHFFFAOYSA-N. SMILES:...
| Keywords: | N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]-cyclopropanecarboxamide |
| Application: | Imidazole-containing compound, JAK1 inhibitor |
| CAS | 1973485-18-5 |
| MW: | 442.5 D |
From 60.00€
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WYneN
Item number: Cay42010-10
A chemoselective probe for protein sulfenylation, selective for sulfenylated proteins over DNTB and 4-DPS, binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection. Formulation: A solid. InChI:...
| Keywords: | Wittig-alkyne N, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-phosphonium, monobromide |
| Application: | Chemoselective protein sulfenylation probe |
| CAS | 3052492-38-0 |
| MW: | 438.3 D |
From 153.00€
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8alpha,9alpha-epoxy Hexahydrocannabinol
Item number: Cay42021-1
An analytical reference standard categorized as a phytocannabinoid metabolite, a metabolite of Delta8-THC, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | 8alpha,9alpha-EEHC, 8alpha,9alpha-epoxy HHC,... |
| Application: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 80513-76-4 |
| MW: | 330.5 D |
From 95.00€
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