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Obeversen
Item number: TGM-T74420-50mg
Description: Obeversen is a DGAT-2 synthesis reducer [1]. Target: Others
| CAS | 2304711-30-4 |
| MW: | 8606.36 D |
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Xalnesiran sodium
Item number: TGM-T74423-50mg
Description: Xalnesiran (sodium) is an siRNA designed for the treatment of chronic hepatitis B (HBV). Target: Others
| CAS | 2538784-49-3 |
| MW: | 22262.12 D |
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BRD7-IN-3
Item number: TGM-T77680-50mg
Description: BRD7-IN-3 (compound 1-78) is a dual inhibitor of bromodomain-containing proteins BRD7 and BRD9, with half-maximal inhibitory concentrations (IC50s) of 1.6 µM for BRD7 and 2.7 µM for BRD9, respectively [1]. Target: Epigenetic Reader Domain
| MW: | 294.35 D |
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Biotinylated-JQ1
Item number: TGM-T74428-50mg
Description: Biotinylated-JQ1 (Biotin-JQ1), a biotinylated derivative of JQ1, selectively binds to the BRD4 bromodomain with high affinity. It effectively inhibits the proliferation of MM1.S multiple myeloma cells, demonstrating an EC50 of 0.4 µM [1]. Target: Others
| CAS | 1635437-52-3 |
| MW: | 829.47 D |
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SJ10542
Item number: TGM-T74429-2mg
Description: SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1]. Target: PROTACs
| CAS | 2789678-92-6 |
| MW: | 818.95 D |
1,355.00€
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ADH-6 TFA
Item number: TGM-T74443-50mg
Description: ADH-6 TFA, a tripyridylamide compound, effectively disrupts the self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD, thereby targeting and disassociating mutant p53 aggregates in human cancer cells. This action restores the transcriptional activity of p53, resulting in cell cycle...
| MW: | 754.67 D |
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EGFR-IN-42
Item number: TGM-T74457-50mg
Description: EGFR-IN-42 (Compound 17b), a potent EGFR inhibitor, demonstrates single-digit nanomolar activity by covalently linking tamoxifen or endoxifen with gefitinib, retaining both ER antagonist activity and EGFR inhibition, resulting in superior anti-cancer activity [1]. Target: Others
| MW: | 846.43 D |
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EGFR-IN-43
Item number: TGM-T74458-50mg
Description: EGFR-IN-43 (Compound 17c) is a highly effective EGFR inhibitor with single-digit nanomolar activity, uniquely combining tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bond, maintaining both ER antagonist activity and EGFR inhibition capabilities, demonstrating exceptional...
| MW: | 860.45 D |
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Y1R probe-1
Item number: TGM-T74459-50mg
Description: Compound 39, also known as Y1R probe-1, is a high-affinity fluorescent probe targeting the Neuropeptide Y Y1 Receptor, with potential applications in cancer research [1]. Target: Others
| CAS | 2773476-41-6 |
| MW: | 1229.3 D |
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c-Myc inhibitor 5
Item number: TGM-T74460-50mg
Description: c-Myc Inhibitor 5 (DA3) is a fluorescent bispurine compound with a long-chain bridge that selectively binds to the c-MYC G-quadruplex, exhibiting a dissociation constant (K D) of 16 µM. Unlike other G4-driven oncogenes, this inhibitor specifically suppresses c-MYC expression [1]. Target: Others
| MW: | 574.77 D |
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SNIPER(TACC3)-11
Item number: TGM-T74462-50mg
Description: SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, significantly reducing its levels and inhibiting the proliferation of FGFR3-TACC3-positive cancer cells [1]. Target: Others
| CAS | 2906151-68-4 |
| MW: | 995.26 D |
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Suc-Gly-Pro-AMC
Item number: TGM-T74482-2mg
Description: Suc-Gly-Pro-AMC, a fibroblast activation protein (FAP)-specific substrate, facilitates the examination of FAP activity [1]. Target: Others
| CAS | 80049-85-0 |
| MW: | 429.42 D |
76.00€
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