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L-Buthionine-(S,R)-Sulfoximine
Item number: Cay14484-250
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM)...
| Keywords: | BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid |
| Application: | Oxidative stress inducer |
| CAS | 83730-53-4 |
| MW: | 222.3 D |
From 132.00€
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Anhydrotetracycline (hydrochloride)
Item number: Cay10009542-50
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to...
| Keywords: | 4-(dimethylamino)-1,4S,4aS,5,12,12aS-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide,... |
| Application: | Antibiotic |
| CAS | 13803-65-1 |
| MW: | 462.9 D |
From 76.00€
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Cisplatin
Item number: Cay13119-50
Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis. It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA...
| Keywords: | cis-Diamminedichloroplatinum, CDDP, Cisplatinum, NSC 119875, (SP-4-2)-diamminedichloro-platinum |
| Application: | Alkylating agent, apoptosis inducer |
| CAS | 15663-27-1 |
| MW: | 300.1 D |
From 73.00€
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Carbenicillin, disodium salt
Item number: 50195.5
Carbenicillin is a bacteriolytic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has Gram-negative coverage which includes Pseudomonas aeruginosa but limited Gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes, although they are more...
| Application: | Antibiotic |
| CAS | 4800-94-6 |
| MW: | 422.37 |
From 183.00€
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Resolvin D2
Item number: Cay10007279-10
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 (RvD2) is produced...
| Keywords: | 7(S),16(R),17(S)-Resolvin D2, RvD2, 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid |
| Application: | Lipid mediator |
| CAS | 810668-37-2 |
| MW: | 376.5 D |
From 235.00€
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FTY720 Phosphate
Item number: Cay10008639-1
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. In vivo, FTY720...
| Keywords: | FTY720P, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate) |
| Application: | Sphingosine analog |
| CAS | 402615-91-2 |
| MW: | 387.5 D |
From 153.00€
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Nuclear Green(TM) LCS1
Item number: ABD-17540
Our Nuclear Green(TM) LCS1 is a non-fluorescent, DNA-selective and cell-permeant dye for analyzing DNA content in living cells. The Nuclear Green(TM) LCS1 has its green fluorescence significantly enhanced upon binding to DNA. It can be used in fluorescence imaging, microplate and flow cytometry applications. This...
| Application: | DNA content analysis |
145.00€
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2-Arachidonoyl Glycerol
Item number: Cay62160-1
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively). Unlike arachidonoyl ethanolamide (AEA, Cay-90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species...
| Keywords: | 2-AG, 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester |
| Application: | CB1 receptor agonist |
| CAS | 53847-30-6 |
| MW: | 378.6 D |
From 60.00€
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Cal-520(TM), potassium salt
Item number: ABD-21140
Cal-520(TM) provides a robust homogeneous fluorescence-based assay tool for detecting intracellular calcium mobilization. Cal-520(TM) AM is a new fluorogenic calcium-sensitive dye with a significantly improved signal to noise ratio and intracellular retention compared to the existing green calcium indicators (such...
| Application: | Calcium detection |
From 434.00€
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RatioWorks(TM) PDMPO
Item number: ABD-21204
The existing pH probes are ill-adapted to study acidic organelles such as lysosomes, endosomes, spermatozoa and acrosomes because their fluorescence is significantly reduced at lower pH. In addition, most of the existing pH probes (such as BCECF and SNARF) are not selectively localized in acidic organelles. The...
| Application: | Fluorescent pH indicator |
145.00€
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FMOC-Lys(5-FITC)-OH
Item number: ABD-5070
A building block for in-sequence Lys labeling by 5-FITC.
| Application: | Building block |
| CAS | 1095493-05-2 |
291.00€
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Nigericin (sodium salt)
Item number: Cay11437-5
Nigericin is a lipophilic potassium ionophore that has been found in S. hygroscopicus. It mediates neutral antiport of potassium and proton ions across mitochondrial membranes. Nigericin (10 µM) induces T. gondii egress in infected human foreskin fibroblasts (HFFs). It also induces NOD-like receptor protein 3...
| Keywords: | NSC 292567,... |
| Application: | Metabolic studies |
| CAS | 28643-80-3 |
| MW: | 747 D |
From 101.00€
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