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PD-1 CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78059
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune...
| Keywords: | SpCas9 lentivirus, CRISPR lentivirus, Cas9 lentivirus, Programmed Cell Death Protein 1 CRISPR, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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LAG3 CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78060
Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to the immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T-cells, Natural Killer cells, B-cells, and plasmacytoid dendritic cells. Its main ligand is the MHC class II, to which it binds with higher affinity than CD4. It...
| Keywords: | Lymphocyte-activation gene 3 CRISPR, CD223 Lentivirus, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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CTLA4 CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78061
CTLA4 (Cytotoxic T-Lymphocyte Associated Protein), also known as CD152, is a protein receptor that functions as an immune checkpoint. It is expressed by activated T-cells and transmits an inhibitory signal to T-cells. CTLA4 is homologous to the T-cell co-stimulatory protein CD28, and both molecules bind to CD80...
| Keywords: | Cytotoxic T-Lymphocyte Associated Protein Lentivirus, CD152 lentivirus, CTLA4 CRISPR, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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TCR CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78062
The T-Cell Receptor (TCR) is found on the surface of T-cells and is responsible for recognizing antigens bound to MHC (Major Histocompatibility Complex) molecules. Activation of the TCR results in activation of downstream NFAT signaling. The TCR consists of a heterodimer of two different protein chains, of which the...
| Keywords: | SpCas9 lentivirus, CRISPR lentivirus, Cas9 lentivirus, T-Cell Receptor CRISPR, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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CD47 CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78063
CD47 (also known as Rh-associated protein, GP42, Integrin-Associated Protein (IAP), or Neurophilin) is an immunoglobulin-like protein that interacts with its receptor, Signal-regulatory protein alpha (SIRPalpha), on macrophages. This binding interaction regulates transmigration, oxidative burst cytokine production,...
| Keywords: | Rh-associated protein CRISPR, GP42 lentivirus, Integrin-Associated Protein (IAP) CRISPR, Neurophilin lentivirus, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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PD-L1 CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78064
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and allows cancer cells to escape immune...
| Keywords: | Programmed Cell Death Protein 1 CRISPR, PD-1 lentivirus, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
*
TIGIT CRISPR/Cas9 Lentivirus (Non-Integrating)
Item number: BPS-78065
TIGIT (T-cell immunoreceptor with Ig and ITIM domains, VSTM3, VSIG9) is a co-inhibitory receptor that is highly expressed in Natural Killer (NK) cells and activated CD4+, CD8+, and regulatory T-cells. Interaction with the Poliovirus Receptor (PVR, CD155) on antigen presenting cells, such as dendritic cells, recruits...
| Keywords: | VSTM3 lentivirus, VSIG9 CRISPR, |
| Application: | Transient knock-down, stable knock-out cell generation |
| Species reactivity: | human |
1,555.00€
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COVID-19 Research
Spike (SARS-CoV-2, D614G) Pseudotyped Lentivirus (eGFP...
Item number: BPS-78035-1
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting...
| Keywords: | 2, |
| Application: | Viral transduction mechanism studies, SARS-CoV-2 Spike/ACE2 neutralizing antibody screening |
| Species reactivity: | SARS-CoV-2 |
From 1,285.00€
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Cas9 Lentivirus (Puromycin Selection)
Item number: BPS-78066
Cas9 (Streptococcus pyogenes CRISPR associated protein 9) is an endonuclease enzyme that, when recruited to a specific DNA sequence by the sgRNA (single guide RNA), introduces a double stranded break into the DNA. This double stranded break is repaired in mammalian cells either through Non-Homologous End Joining or...
| Keywords: | Cas9 Lentivirus, CRISPR lentivirus, spCas9 lentivirus, |
| Application: | Transient Cas9 expression in target cells, stable Cas9 over-expressing cell line generation |
| Species reactivity: | human |
1,248.00€
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COVID-19 Research
Spike (SARS-CoV-2, alpha B.1.1.7 Variant) Pseudotyped...
Item number: BPS-78112-1
The Spike (SARS-CoV-2, UK variant) Pseudotyped Lentivirus were produced with SARS-CoV-2 UK Variant Spike (Genbank Accession #QHD43416.1 with UK variant mutations, see below for details) as the envelope glycoproteins instead of the commonly used VSV-G. These pseudovirions contain the firefly luciferase gene driven by...
| Keywords: | 2, |
| Application: | Viral transduction studies, neutralizing antibody screening |
| Species reactivity: | SARS-CoV-2 |
From 1,307.00€
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TCR Activator Lentivirus (EF1a Promoter/Hygromycin)
Item number: BPS-79894-EH
The TCR Activator Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a gene for a membrane-bound, engineered T cell receptor (TCR) activator...
| Application: | TCR activator expression, T cell stimulation, stable cell line generation |
1,248.00€
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Cas9 Lentivirus (Hygromycin Selection)
Item number: BPS-78067
Cas9 Lentivirus can be used to generate Cas9 expressing cells in almost any mammalian cell line. Cells stably expressing Cas9 can then be transduced or electroporated with sgRNA targeting a gene of interest to quickly generate knock-out cell pools or cell lines. The Cas9 Lentiviruses are replication incompetent,...
| Keywords: | Cas9 Lentivirus, CRISPR lentivirus, spCas9 lentivirus, CRISPR pseudovirus, Cas9 pseudovirion, |
| Application: | Transient Cas9 expression, stable Cas9 over-expressing cell line generation (hygromycin selection) |
1,248.00€
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