Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner  BPS Bioscience offers infection systems based on lentiviruses, adeno-associated... read more »
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Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

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Anti-BCMA CAR Lentivirus (Clone C11D5.3 ScFv-CD8-4-1BB-CD3zeta)
Anti-BCMA CAR Lentivirus (Clone C11D5.3...

Item number: BPS-78655

The anti-BCMA CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragment) of anti-BCMA (clone C11D5.3) linked...
Keywords: BCM, CD269, TNFRSF17, B-cell maturation protein, Tumor necrosis factor receptor superfamily member 17,
Application: Positive control for anti-BCMA CAR evaluation in T cells, transduction optimization studies
Species reactivity: human
1,752.00€ *
Review
FcRL5 Lentivirus
FcRL5 Lentivirus

Item number: BPS-78715

The FcRL5 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human FcRL5 (NM_031281.3) driven by an EF1A promoter and a puromycin selection...
Keywords: FcRH5, FCRH5, FCRL5, FcRL5, CD307e, BXMAS1, FcR-like protein 5, Fc receptor homolog 5, Fc receptor-like protein 5, Immune...
Application: Stable cell line expressing generation with puromycin selection
Species reactivity: human
1,570.00€ *
Review
Negative Control Lentivirus (Firefly Luciferase)
Negative Control Lentivirus (Firefly Luciferase)

Item number: BPS-79578

The Negative Control Lentivirus (Firefly Luciferase) are replication incompetent, HIV-based, VSV-G pseudo typed lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of...
Application: Background reporter activity determination, specificity establishment
1,402.00€ *
Review
ISRE Luciferase Reporter Lentivirus (JAK/STAT Signaling Pathway)
ISRE Luciferase Reporter Lentivirus (JAK/STAT Signaling...

Item number: BPS-79824

The JAK/STAT pathway is activated by various cytokines and growth factors and plays a critical role in cell growth, hematopoiesis, and immune response. In mammals, there are four JAKs (JAK1, JAK2, JAK3 and TYK2) and seven STAT proteins. IFNalpha is a Type I interferon. Binding of IFNalpha to its receptor leads to...
Keywords: JAK reporter, STAT reporter, ISRE reporter, IFN, lentivirus reporter,,
Application: Type I IFN ind. JAK/STAT signaling pathway activator/inhibitor screening, stable cell line generation
Species reactivity: human
1,285.00€ *
Review
TEAD Luciferase Reporter Lentivirus
TEAD Luciferase Reporter Lentivirus

Item number: BPS-79833

The Hippo pathway regulates cell proliferation and cell death. It is activated by high cell density and cell stress to stop cell proliferation and induce apoptosis. The mammalian Hippo pathway comprises MST kinases and LATS kinases. When the Hippo pathway is activated, MST kinases phosphorylate LATS kinases, which...
Keywords: TEAD Luciferase Reporter Lentivirus (Hippo Pathway), MST kinases, LATS kinases, HIV-based, VSV-G,
Application: Hippo pathway activator / inhibitor screening, stable cell line generation
Species reactivity: human
1,373.00€ *
Review
STAT5 Luciferase Reporter Lentivirus
STAT5 Luciferase Reporter Lentivirus

Item number: BPS-79745

The STAT5 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of...
Keywords: VSV-G, HIV,
Application: Activator / inhibitor screening, stable luciferase reporter cell line generation
Species reactivity: human
1,307.00€ *
Review
IL-2 Promoter Luciferase Reporter Lentivirus
IL-2 Promoter Luciferase Reporter Lentivirus

Item number: BPS-79825

The IL-2 Promoter Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the human IL-2...
Keywords: IL-2 Promoter reporter, lentivirus reporter, HIV reporter, VSV-G reporter,
Application: Activator / inhibitor screening, IL-2 promoter luciferase reporter stable cell line generation
Species reactivity: human
1,248.00€ *
Review
FcGRIIB (CD32B) Lentivirus
FcGRIIB (CD32B) Lentivirus

Item number: BPS-79877

Fc Gamma Receptor 2B (FcGR2B, FcgammaRIIB), also known as CD32B, is a 'low affinity' receptor for Immunoglobulin G (IgG). FcGR2B is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. It is the predominant Fc receptor present on B cells. Crosslinking of...
Keywords: CD32B Lentivirus,
Application: Transient FcGRIIB expression, stable cell line generation
Species reactivity: human
1,555.00€ *
Review
Renilla Luciferase (Rluc) Lentivirus (Puromycin)
Renilla Luciferase (Rluc) Lentivirus (Puromycin)

Item number: BPS-79565-P

The Renilla Luciferase (Rluc) Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles constitutively express Renilla luciferase under a CMV promoter.
Keywords: Renilla-type luciferase, Coelenterazine h 2-monooxygenase, Renilla-luciferin 2-monooxygenase,
Application: Internal control, dual-luciferase reporter assays
Species reactivity: sea pansy
1,248.00€ *
Review
Secreted Gaussia Luciferase Lentivirus CMV Promoter
Secreted Gaussia Luciferase Lentivirus CMV Promoter

Item number: BPS-79892-C

The Secreted Gaussia Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles constitutively express secreted Gaussia luciferase under a CMV...
Keywords: Luciferase,
Application: Sensitive reporter, biological process monitoring, stable cell line generation
1,248.00€ *
Review
Secreted Gaussia Luciferase Lentivirus EF1a Promoter
Secreted Gaussia Luciferase Lentivirus EF1a Promoter

Item number: BPS-79892-E

The Secreted Gaussia Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles constitutively express secreted Gaussia luciferase under a CMV...
Keywords: Luciferase,
Application: Sensitive reporter, biological process monitoring, stable cell line generation
1,248.00€ *
Review
Non-secreted Gaussia Luciferase Lentivirus (CMV Promoter)
Non-secreted Gaussia Luciferase Lentivirus (CMV Promoter)

Item number: BPS-79893-C

The Non-secreted Gaussia Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles constitutively express Gaussia luciferase lacking the...
Keywords: Luciferase,
Application: Sensitive reporter, biological process monitoring, stable cell line generation
1,248.00€ *
Review
4 from 29 pages