Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner  BPS Bioscience offers infection systems based on lentiviruses, adeno-associated... read more »
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Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

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FcER1G Lentivirus
FcER1G Lentivirus

Item number: BPS-79878

FcER1G is an adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, FcER1G mediates allergic inflammatory signaling in mast cells. FcER1G is also a...
Keywords: FCER1G, FcRgamma, FceRI gamma, Fc-epsilon RI-gamma, Fc receptor gamma-chain, IgE Fc receptor subunit gamma, High affinity...
Application: Transient FcER1G expression, stable cell line generation
Species reactivity: human
1,248.00€ *
Review
Firefly Luciferase Lentivirus (UbC Promoter)
Firefly Luciferase Lentivirus (UbC Promoter)

Item number: BPS-79880

The Firefly Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by a UbC (ubiquitin C) promoter. The...
Keywords: UbC lentivirus,
Application: Transduction positive control, transduction optimization, stable cell line generation
Species reactivity: common eastern firefly
1,248.00€ *
Review
Renilla Luciferase (Rluc) Lentivirus (G418)
Renilla Luciferase (Rluc) Lentivirus (G418)

Item number: BPS-79565-G

The Renilla Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles constitutively express Renilla luciferase under a CMV promoter.
Keywords: Renilla-type luciferase, Coelenterazine h 2-monooxygenase, Renilla-luciferin 2-monooxygenase,
Application: Internal control, stable cell line generation
1,285.00€ *
Review
NFAT eGFP Reporter Lentivirus
NFAT eGFP Reporter Lentivirus

Item number: BPS-79922

The NFAT eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an enhanced GFP gene driven by the NFAT response element located...
Application: Activator / inhibitor screening, stable cell line generation
1,424.00€ *
Review
COVID-19 Research
TMPRSS2 Lentivirus
TMPRSS2 Lentivirus

Item number: BPS-78011-1

Human transmembrane serine protease 2 (TMPRSS2) is an enzyme primarily expressed by endothelial cells across the respiratory and digestive tracts. It is involved in viral entry and spread of coronaviruses including SARS-CoV-2, the virus that causes COVID19. TMPRSS2 primes the spike protein by cleaving at the S1/S2...
Keywords: PRSS10,
Application: Transient TMPRSS2 expression in target cells, stable TMPRSS2 over-expressing cell line generation
Species reactivity: human
From 1,248.00€ *
Review
Negative Control eGFP Reporter Lentivirus
Negative Control eGFP Reporter Lentivirus

Item number: BPS-79927

The Negative Control eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an enhanced Green Fluorescent Protein (eGFP) gene under the...
Keywords: enhanced GFP reporter, negative control pseudovirion, eGFP pseudovirus negative control,
Application: eGFP reporter activity background determination, establishing lentivirus reporter system specificity
Species reactivity: mammalian
1,307.00€ *
Review
Omicron Research
Spike (B.1.1.529, Omicron Variant) Pseudotyped Lentivirus (Luc Reporter)
Spike (B.1.1.529, Omicron Variant) Pseudotyped Lentivirus...

Item number: BPS-78348-1

The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of the viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting...
Keywords: 2,
Application: Neutralizing antibody screening/titration
Species reactivity: SARS-CoV-2
From 1,343.00€ *
Review
SRE Luciferase Reporter Lentivirus
SRE Luciferase Reporter Lentivirus

Item number: BPS-78627

The SRE (Serum Response Element) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven...
Keywords: Luciferase, Luciferin 4-monooxygenase,
Application: Activator / inhibitor screening, SRE Luciferase Reporter stable cell lines generation
Species reactivity: common eastern firefly
1,307.00€ *
Review
NFAT Luciferase Reporter Lentivirus-79579-P
NFAT Luciferase Reporter Lentivirus-79579-P

Item number: BPS-79579-P

The NFAT Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the NFAT response element...
Keywords: Luciferase, Luciferin 4-monooxygenase,
Application: Activator / inhibitor screening, NFAT Luciferase Reporter stable cell line generation
Species reactivity: common eastern firefly
1,373.00€ *
Review
AAV2 ZsGreen
AAV2 ZsGreen

Item number: BPS-78444

Adeno-Associated Virus Serotype 2 (AAV2) is the best characterized AAV serotype. Nearly all recombinant AAV serotypes utilize the AAV2 inverted terminal repeats (ITRs). AAV2 requires the expression of Heparan Sulfate Proteoglycan (HSPG) on the surface of host cells for cell binding and internalization. Of nearly all...
Keywords: Green fluorescent protein,
Application: Transduction positive control, transduction assay optimization, expression tracking over time
819.00€ *
Review
HRE Luciferase Reporter Lentivirus
HRE Luciferase Reporter Lentivirus

Item number: BPS-78668

The Hypoxia Response Element (HRE) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by four copies...
Keywords: Luciferase, Luciferin 4-monooxygenase,
Application: Activator / inhibitor screening, stable cell line generation
Species reactivity: human
1,307.00€ *
Review
XRE Luciferase Reporter Lentivirus (AhR Signaling)
XRE Luciferase Reporter Lentivirus (AhR Signaling)

Item number: BPS-78672

The Xenobiotic response element (XRE) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by three...
Keywords: Luciferase, Luciferin 4-monooxygenase,
Application: Activator / inhibitor screening, stable cell line generation
Species reactivity: human
1,307.00€ *
Review
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