Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner  BPS Bioscience offers infection systems based on lentiviruses, adeno-associated... read more »
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Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

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NF-kappaB Luciferase Reporter Lentivirus
NF-kappaB Luciferase Reporter Lentivirus

Item number: BPS-79564

The NF-kappaB Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by four copies of the...
Application: Activator / inhibitor screening
1,373.00€ *
Review
Firefly Luciferase Lentivirus Puromycin
Firefly Luciferase Lentivirus Puromycin

Item number: BPS-79692-P

The Firefly Luciferase Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types mammalian cells, including primary and non-dividing cells. This virus constitutively express firefly luciferase under a CMV promoter.
Application: Transduction, positive control, optimization
Host: human cells
1,373.00€ *
Review
FcGRIIIA (CD16a) Lentivirus
FcGRIIIA (CD16a) Lentivirus

Item number: BPS-79876

Fc Gamma Receptor IIIa (FcGRIIIA, FcgammaRIIIA), also known as CD16a, is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, antibody-dependent cytotoxicity and clearance of immune complexes. The human FcgammaRIIIa displays a dimorphism in the position of residue...
Keywords: CD16a Lentivirus,
Application: Transient FcGRIIIA expression, stable cell line generation
Species reactivity: human
1,555.00€ *
Review
COVID-19 Research
ACE2 Lentivirus
ACE2 Lentivirus

Item number: BPS-79944

Human Angiotensin converting enzyme 2 (ACE2), also known as ACEH, is an integral membrane protein found on the surface of cells in the lungs, arteries, heart, kidney, and intestines. ACE2 serves as the entry point into cells for some coronaviruses, including the two strains that caused outbreaks of Severe acute...
Keywords: Angiotensin converting enzyme 2, ACEH, SARS-CoV, Coronavirus, COVID-19, SARS-CoV-2, ACE2 cells, ACE2 cell assay, covid19,
Application: Transient expression, stable cell line generation
Species reactivity: human
1,307.00€ *
Review
Firefly Luciferase-eGFP Lentivirus (G418)-79980-G
Firefly Luciferase-eGFP Lentivirus (G418)-79980-G

Item number: BPS-79980-G

The Firefly Luciferase-eGFP Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types mammalian cells, including primary and non-dividing cells. These viruses contain a firefly luciferase and eGFP cassette (Luc-P2A-eGFP) driven by...
Keywords: GFP, Green fluorescent protein,
Application: Positive control/transduction, transduction optimization
Species reactivity: mammalian
1,373.00€ *
Review
Anti-CD22 CAR Lentivirus (Clone m971 ScFv-CD8-4-1BB-CD3zeta)
Anti-CD22 CAR Lentivirus (Clone m971 ScFv-CD8-4-1BB-CD3zeta)

Item number: BPS-78608

The anti-CD22 CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragment) of anti-CD22 (clone m971) linked to a...
Keywords: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell...
Application: Positive control for anti-CD22 CAR evaluation in T cells, transduction optimization
Species reactivity: human
1,708.00€ *
Review
DLL3 Lentivirus
DLL3 Lentivirus

Item number: BPS-78909

DLL3 (Delta-like protein 3) Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. These particles contain human DLL3 (NM_016941.3) driven by a CMV promoter and a puromycin selection...
Keywords: DLL3, Delta3, Delta-like protein 3, Drosophila Delta homolog 3,
Application: Protein expression, cell pool / stable cell line generation (puromycin selection)
Species reactivity: human
1,490.00€ *
Review
CRE/CREB Luciferase Reporter Lentivirus
CRE/CREB Luciferase Reporter Lentivirus

Item number: BPS-79580

The main role of the cAMP response element, or CRE, is mediating the effects of Protein Kinase A (PKA) by way of transcription. Upon phosphorylation, CREB forms a functionally active dimer that binds the CRE element within the promoters of target genes and activates transcription. CRE is at the focus of many...
Keywords: CREB1, CREB-1, cAMP-responsive element-binding protein 1, Cyclic AMP-responsive element-binding protein 1
Application: Activator / inhibitor screening
Species reactivity: human
1,307.00€ *
Review
SBE Luciferase Reporter Lentivirus (TGFbeta/SMAD Pathway)
SBE Luciferase Reporter Lentivirus (TGFbeta/SMAD Pathway)

Item number: BPS-79806

The SBE Luciferase Reporter Lentivirus (TGFbeta/SMAD signaling pathway) are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene...
Keywords: SBE reporter, TGFbeta reporter, TGFbeta reporter, SMAD reporter,
Application: TGFbeta/SMAD signaling pathway activator / inhibitor screening, stable cell line generation
Species reactivity: human
1,373.00€ *
Review
AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)
AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

Item number: BPS-79823

The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP...
Keywords: JNK reporter, AP-1 cell line, activator protein-1 lentivirus,
Application: JNK signaling pathway activator / inhibitor screening, stable cell line generation
Species reactivity: human
1,248.00€ *
Review
STAT3 Luciferase Reporter Lentivirus
STAT3 Luciferase Reporter Lentivirus

Item number: BPS-79744

The STAT3 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of...
Keywords: Acute-Phase Response Factor, APRF, ADMIO1, HIES,
Application: Activator / inhibitor screening, stable luciferase reporter cell line generation
Species reactivity: human
1,351.00€ *
Review
IL-8 Promoter Luciferase Reporter Lentivirus
IL-8 Promoter Luciferase Reporter Lentivirus

Item number: BPS-79827

The IL-8 Promoter Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the human IL-8...
Keywords: IL-8 Promoter reporter, lentivirus reporter, HIV reporter, VSV-G reporter,
Application: Activator / inhibitor screening, IL-8 promoter luciferase reporter stable cell line generation
Species reactivity: human
1,248.00€ *
Review
2 from 29 pages