Virus-based Tools: Lentivirus, AAV und VSV

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated viruses (AAV) or the vesicular stomatitis virus (VSV). Lentiviruses can be used to generate stably transfected cell lines, they have a high infection rate (>90%), provide high levels of subsequent protein expression, and can be used both in vitro and in vivo. Learn more about lentiviruses and potential applications in our blog. AAVs are useful as viral vectors because they can carry a gene of interest up to 5 kb in length. Because they lead to stable gene expression and they can be used safely due to their low immunogenicity, AAVs are the vectors of choice for the development of many gene therapies. The enveloped VSV provides a valuable tool for studying viral entry, replication, and assembly. VSV-G, the glycoprotein of the virus, is responsible for the attachment and entry of VSVs into the host cell and is often used to pseudotype viral vectors.

Virus-based tools can be used to manipulate genetic material and study viral infections. Our partner BPS Bioscience offers infection systems based on lentiviruses, adeno-associated... read more »

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Enhanced GFP Lentivirus (Hygromycin)

Item number: BPS-78639-H

Enhanced green fluorescent protein (eGFP) is a modified (F64L and S65T mutations) version of the native GFP protein isolated from jellyfish (Aequorea victoria), with increased fluorescence and more efficient folding. The Enhanced GFP Lentivirus are replication-incompetent, HIV based, VSV-G pseudotyped lentiviral...

Keywords:	GFP, Green fluorescent protein,
Application:	Transduction positive control/assay optimization/efficiency tracking, stable cell line generation

1,307.00€ *

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Enhanced GFP Lentivirus (Puromycin)

Item number: BPS-78639-P

Keywords:	GFP, Green fluorescent protein,
Application:	Transduction positive control/assay optimization/efficiency tracking, stable cell line generation

1,307.00€ *

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AAV3 Luciferase

Item number: BPS-78454

Adeno-Associated Virus Serotype 3 (AAV3) shares 82% sequence homology with AAV2, and like AAV2, requires the Heparan Sulfate Proteoglycan (HSPG) receptor for cell attachment. AAV3 vectors transduce human liver cancer cells extremely efficiently because AAV3 utilizes the human Hepatocyte Growth Factor Receptor...

Keywords:	Luciferase, Luciferin 4-monooxygenase,
Application:	Positive transduction control, transduction assays optimization, temporal protein expression tracking
Species reactivity:	human

819.00€ *

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AAV5 Luciferase

Item number: BPS-78456

Adeno-Associated Virus Serotype 5 (AAV5) differs from other parvovirus serotypes according to serological and DNA hybridization data, and AAV5 also uses different inverted terminal repeats (ITRs) compared to other AAV serotypes. AAV5 is the most efficient vector for transducing sensory neurons and is effective at...

Keywords:	Luciferase, Luciferin 4-monooxygenase,
Application:	Positive transduction control, transduction assays optimization, temporal protein expression tracking
Species reactivity:	human

819.00€ *

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AAV6 Luciferase

Item number: BPS-78457

Adeno-Associated Virus serotype 6 (AAV6) appears to be related to AAV1 by sequence analysis and shows the best transduction efficiency in pancreatic beta-cells compared to other AAV serotypes. AAV6 vectors are also particularly effective in the transduction of human prostate, breast, and liver cancer cells. These...

Keywords:	Luciferase, Luciferin 4-monooxygenase,
Application:	Positive transduction control, transduction assays optimization, temporal protein expression tracking
Species reactivity:	human

819.00€ *

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AAV8 Luciferase

Item number: BPS-78458

Adeno-Associated Virus serotype 8 (AAV8) was isolated from rhesus monkey tissue, and the AAV8 rep and cap nucleotide sequences have 88% homology with AAV7 and 82% with AAV2. AAV8 exhibits greater transduction efficiency in the liver than other AAV serotypes. AAV8 and 9 have recently been used to correct...

Keywords:	Luciferase, Luciferin 4-monooxygenase,
Application:	Positive transduction control, transduction assays optimization, temporal protein expression tracking
Species reactivity:	human

819.00€ *

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AAV9 Luciferase

Item number: BPS-78459

Adeno-Associated Virus serotype 9 (AAV9) is one of the most promising serotypes for gene therapy applications. AAV9 transduces a wide range of tissue types, including cardiac and skeletal muscle, liver, pancreas, and eye tissue. AAV8 and AAV9 have recently been used to correct disease-causing mutations and improve...

Keywords:	Luciferase, Luciferin 4-monooxygenase,
Application:	Positive transduction control, transduction assays optimization, temporal protein expression tracking
Species reactivity:	human

819.00€ *

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AAV1 SaCas9

Item number: BPS-78479

Adeno-Associated Virus Serotype 1 (AAV1) exhibits high homology with other AAV serotypes. AAV1 efficiently transduces muscle tissue, as determined by a region of the capsid protein VP1 (amino acids 350 to 430) which functions as a major determinant of tissue tropism. Cas9 is an endonuclease enzyme that introduces a...

Keywords:	SaCas9, CRISPR-associated endonuclease Cas9,
Application:	SaCas9 expression to enable genome editing
Species reactivity:	human

819.00€ *

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AAV2 SaCas9

Item number: BPS-78480

Adeno-Associated Virus serotype 2 (AAV2) is the best characterized AAV serotype. Nearly all recombinant AAV serotypes utilize the AAV2 inverted terminal repeats (ITRs). AAV2 requires the expression of Heparan Sulfate Proteoglycan (HSPG) on the surface of host for cells for binding and internalization. Of nearly all...