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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-82378 | 50 µl | - | - |
3 - 15 business days* |
2,141.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3zeta, IL-15/IL-15Ra) are replication... more
Product information "Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3zeta, IL-15/IL-15Ra)"
The Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3zeta, IL-15/IL-15Ra) are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv portion of anti-CD19 (clone FMC63) linked to a 4th generation CAR (Chimeric Antigen Receptor) containing the CD8 hinge and transmembrane domains, 4-1BB and CD3zeta signaling domains. This construct also includes a 2A-IL15/IL-15 receptor alpha (IL15Ra) sequence downstream of the anti-CD19 CAR cassette to create armored CAR-T cells by overexpressing IL-I5 and IL-15Ra. (Figure 1). Note: This product transduces the same construct as the anti-CD19 CAR Lentiviruses (CD19 ScFv-CD8-4-1BB-CD3zeta) (#78600, 78601, 78602, 78775), but differs in a key aspect: 82378, described here, is constructed with an IL15/IL-15 receptor alpha (IL15Ra) sequence downstream of the anti-CD19 CAR cassette. Figure 1. Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-CD28-CD3zeta, IL-15/IL-15Ra) construct diagrams.(A) Schematic of the lenti-vector used to generate the anti-CD19 CAR lentivirus. The vector is a SIN vector, and it contains the IL15/IL-15 receptor alpha (IL15Ra) sequence downstream of the anti-CD19 CAR cassette. (B) Construct diagram showing components of the anti-CD19 CAR.
| Keywords: | CD19, B-lymphocyte antigen CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte surface antigen B4, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 82378 |
Properties
| Application: | Positive control, Transduction optimization |
| Species reactivity: | human |
Database Information
| KEGG ID : | K06465 | Matching products |
| UniProt ID : | P15391 | Matching products |
| Gene ID : | GeneID 930 | Matching products |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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