Membrane TL1A CHO Cell Line

Membrane TL1A CHO Cell Line is a clonal CHO cell line stably expressing an engineered, cleavage-resistant form of TL1A (TNF-like ligand 1A), that enforces its cell surface localization. This cell line has been validated by flow cytometry. Note: This cell line is not suitable for co-culture activation of TL1A-Responsive Luciferase Reporter Jurkat Cell line (#78811). For co-culture activation of TL1A-Responsive Luciferase Reporter Jurkat Cell line, please use TL1A CHO Cell line (#83033). TL1A, also called TNFSF15, is a member of the tumor necrosis factor family. It is expressed in different immune cells, such as monocytes, macrophages, dendritic cells, T cells, and non-immune cells. It exists in a membrane-bound (mTL1A) and a soluble form (sTL1A), which seem to play different roles in adaptive and innate cells. TL1A competitively binds to DR3 (death receptor 3), having a higher affinity for DcR3 (decoy receptor 3), providing a stimulatory signal for downstream signaling pathways. It then regulates proliferation, activation, apoptosis, and chemokine production in effector cells. The role of DR3 in T cell activation, and consequently in cytokine secretion and cell proliferation, makes it an attractive target in cancer therapy. Inhibition of DR3-TL1A interaction has substantial therapeutic potential in the treatment of solid tumors. Non-secreted TL1A has a role in remodeling the airways in patients suffering from asthma. The study of membrane-bound TL1A and development of blockers specific to this molecule may prove highly beneficial in immune-related disorders.