HLA-G1 TCR Activator CHO Cell Line

HLA-G1 TCR activator CHO Cell Line is a CHO-K1 cell line constitutively expressing human B2M (beta-2 microglobulin) and HLA-G1 (human leukocyte antigen) (NM_001363567.2) and an engineered TCR (T cell receptor) activator. This cell line was functionally validated with anti-LILRB2 and anti-HLA-G1 neutralizing antibodies in co-culture assays. Human Leukocyte Antigen-G (HLA-G) is a non-classical MHC-I (major histocompatibility complex) heavy chain receptor, composed of HLA-G and beta2-microglobulin (B2M). It has several isoforms, some of which are secreted while others are membrane bound. It is involved in fetal-maternal tolerance. In addition, it can serve as a marker for diabetic retinopathy and participate in immune evasion in cancer. The understanding of the association between HLA alleles and diseases will allow a refinement of therapeutic strategies.