HLA-A*03:01 A549 Cell Line

The HLA-A*03:01 A549 Cell Line is a A549 human lung cancer cell line that was generated by selecting a single clone of B2M Knockout A549 cells (#82871) transduced with lentivirus expressing B2M (beta-2 microglobulin) HLA (human leukocyte antigen)-A*03:01 driven by an EF1a promoter (#82425). This cell line has been validated by flow cytometry. Purchase of this cell line is for research purposes only, commercial use requires a separate license. Human Leukocyte Antigen-A (HLA-A) is an MHC-I (major histocompatibility complex) heavy chain receptor, composed of HLA-A and beta2-microglobulin (B2M). There are over 200 genes encoding HLA variants and this variability plays a critical role in adaptive immunity. HLA-A*03 has been used as predictive biomarker in relation to the response of patients to ICI (immune checkpoint inhibitors). HLA-A*03:01 in particular has been linked to the development of stronger side effects to one of the COVID-19 vaccines. The understanding of the association between HLA alleles and diseases will allow a refinement of therapeutic strategies.