HLA-A*02:01 A549 Cell Line

The HLA-A*02:01 A549 Cell Line is an A549 human lung cancer cell line generated by selecting a single clone of B2M Knockout A549 cells (#82871) transduced with lentivirus expressing B2M (beta-2 microglobulin) HLA (human leukocyte antigen)-A*02:01 driven by an EF1a promoter (#82424). This cell line has been validated by flow cytometry and a co-culture assay response to Tebentafusp. Purchase of this cell line is for research purposes only, commercial use requires a separate license. Human Leukocyte Antigen-A (HLA-A) is an MHC-I (major histocompatibility complex) heavy chain receptor, composed of HLA-A and beta2-microglobulin (B2M). There are over 200 genes encoding HLA variants and this variability plays a critical role in adaptive immunity. HLA-A*02 is one of the most common members of class I types, with more than 300 variants HLA class I involved in presenting peptides that are typically between 8 to 11 amino acids. HLAA*02:01 can bind 15-mer peptides, which can then be recognized by T cells. Studies in SCLC (small cell lung cancer) patients have shown that an ATAD2 (ATPase family AAA domain-containing protein 2) immunopeptide can be used in HLA-A*02-01-restricted patients with high reactivity. HLA-A*02:01 abilities can be exploited in cancer therapy.