Claudin-17 (CLDN17) CHO Cell Line

Claudin-17 (CDLN17) CHO Cell Line is a CHO cell line that expresses human Claudin-17 (NM_012131.3) under the control of a cytomegalovirus (CMV) promoter. This cell line was generated by transfection with human Claudin-17 (accession number NM_012131.3) followed by geneticin selection and limited dilution. Individual clones were screened for Claudin-17 expression levels by flow cytometry, and a clone was selected to generate this cell line. This cell line has been validated by flow cytometry. Human claudin 17 (CLDN17) is a tight junction protein with a complex and tissue-dependent role in cancer, sometimes acting as a tumor suppressor and other times as a promoter. In some contexts, like in oral cancer, CLDN17 expression is downregulated, and its restoration has been shown to inhibit cancer cell invasion and migration by blocking the epithelial-mesenchymal transition (EMT) process. However, in other cancers such as hepatocellular carcinoma (HCC), high CLDN17 expression is associated with poor prognosis and increased metastasis, with the Tyk2/STAT3 (TYK2-mediated Janus kinase (JAK)/Signal Transducer and Activator of Transcription) signaling pathway identified as a potential mechanism. Given this context-specific behavior, scientists are investigating CLDN17 as a potential diagnostic or prognostic biomarker.