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Track device being used
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-78757 | 2 vials | - | - |
3 - 15 business days* |
18,012.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This cell line was generated from TCR Knockout NFAT Luciferase Reporter Jurkat Cell Line... more
Product information "CD8+ TCR Knockout NFAT-Luciferase Reporter Jurkat Cell Line"
This cell line was generated from TCR Knockout NFAT Luciferase Reporter Jurkat Cell Line (BPS-78556) by exogeneous overexpression of human CD8 (NM_001768.6) using lentiviral transduction (CD8a Lentivirus, BPS-78648). To achieve knockout of TCR (T Cell Receptor), the TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRalpha/beta chains were genetically removed by CRISPR/Cas9 genome editing from recombinant Jurkat cells stably expressing the firefly luciferase gene under the control of NFAT response elements. TCRalpha/beta knockout in the TCR Knockout NFAT-Luciferase Reporter Jurkat cells was confirmed by genomic sequencing and by flow cytometry and expression of CD8 was confirmed by flow cytometry. The cell line has been functionally validated and does not respond to anti-CD3 agonist antibodies, as opposed to parental NFAT-Luciferase Reporter Jurkat cells (BPS-60621).
| Keywords: | MAL, CD8a, CD8A, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 78757 |
Properties
| Application: | TCR studies, study activation of transgenic TCR by cognate peptide(s)/MHC1-expressing APCs |
| Species reactivity: | human |
Database Information
| KEGG ID : | K06458 | Matching products |
| UniProt ID : | P01732 | Matching products |
| Gene ID | GeneID 925 | Matching products |
Handling & Safety
| Storage: | Liquid nitrogen |
| Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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