CD40/NF-kappaB Reporter (Luc) - HEK293 Stable Cell Line

Recombinant HEK293 cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5, TNFRSF5). Expression is confirmed by real-time qPCR and Western Blot. This NF-kappaB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by human CD40 ligand, NF-kappaB transcription factor binds to the DNA response elements to induce transcription of the luciferase gene.