Cadherin 17 (CDH17) HEK293 Cell Line

Cadherin 17 (CDH17) HEK293 Cell Line is a HEK293 cell line expressing CDH17 (Cadherin 17, NM_004063.4) under the control of the Elongation Factor 1 alpha (EF1alpha) promoter. This cell line was generated by lipophilic transfection followed by zeocin selection and limited dilution. Individual clones were screened for CDH17 expression levels by flow cytometry, and a high expressing clone was selected to generate this cell line. This cell line has been validated by flow cytometry. Human CDH17 (Cadherin 17) is an oncofetal protein that is reactivated in adult tissues to drive the progression of various diseases, especially gastrointestinal cancers. Its overexpression is strongly associated with gastrointestinal adenocarcinomas, including colorectal, gastric, and pancreatic cancers. CDH17's role extends to promoting key cancer hallmarks like cell proliferation, invasion, and metastasis. As a cell adhesion molecule, CDH17 facilitates metastatic spread by interacting with other proteins, such as integrins, and mediating cell-to-cell junctions within tumor clusters. Furthermore, CDH17 expression helps maintain the "stemness" of cancer cells, which is linked to tumor recurrence and resistance to chemotherapy.