BAFF/APRIL Responsive TACI-NF-kappaB Luciferase Reporter HEK293 Cell Line

The BAFF/APRIL Responsive TACI-NF-kappaB Luciferase Reporter HEK293 Cell Line is a HEK293 cell line that expresses full-length human TACI (transmembrane activator and CAML interactor, also known as Tumor necrosis factor receptor superfamily member 13B or CD267) (NM_012452.3) under the control of a CMV promoter, for high constitutive expression, and an inducible firefly luciferase reporter controlled by the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) Response Element located upstream of a minimal promoter. Upon ligand binding, TACI will initiate the NF-kappaB signaling pathway, leading to expression of the NF-kappaB-controlled luciferase reporter. This cell line has been validated by flow cytometry and has been shown to respond to BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand). Interested in screening and profiling inhibitors, blocking antibodies, or activators of TACI signaling without the need to purchase and license the cell line? Check out our Cell Signaling Pathway Screening.