Rat ELAV1 (ELAV-like protein 1) ELISA Kit (RTFI01439)

Rat ELAV1 (ELAV-like protein 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Rat ELAV1 (ELAV-like protein 1) in serum, plasma & cell culture supernatant samples. The Rat ELAV1 (ELAV-like protein 1) ELISA Kit accurately measures natural Rat ELAV1 (ELAV-like protein 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Rat ELAV1 (ELAV-like protein 1) peptide. Protein function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR. [The UniProt Consortium]