RalA Activation Assay Kit

Configuration-specific monoclonal antibody that recognizes Ral-GTP, but not Ral-GDP. The only available RalA activation assay kit directly measures the level of RalA-GTP. Providing shorter experimental time. Could be used to monitor the activation of Ral in cells and in tissues by immunohistochemistry. Protein function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. [The UniProt Consortium]