Rabbit tissue inhibitors of metalloproteinase 1, TIMP-1 ELISA Kit

Sample Types: serum, plasma, cell culture supernates , tissue homogenates Detection Range: 15.6 pg/mL-1000 pg/mL Sensitivity: 7.8 pg/mL Assay Principle: quantitative Measurement: CompetitiveAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. [The UniProt Consortium]