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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NB-82501 | 30 assays | - | - |
3 - 16 business days* |
1,068.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Configuration-specific monoclonal antibody that recognizes Rab7-GTP, but not Rab7-GDP. The only... more
Product information "Rab7 Activation Assay Kit"
Configuration-specific monoclonal antibody that recognizes Rab7-GTP, but not Rab7-GDP. The only available Rab7 activation assay kit directly measures the level of Rab7-GTP. Providing shorter experimental time. Could be used to monitor the activation of Rab7 in cells and in tissues by immunohistochemistry. Protein function: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. [The UniProt Consortium]
Keywords: | RAB7, RAB7A, Ras-related protein Rab-7a |
Supplier: | NewEast Biosciences |
Supplier-Nr: | 82501 |
Properties
Application: | IP/WB G-Protein Activation assay |
Species reactivity: | vertebrates |
Format: | Membrane Based |
Database Information
KEGG ID : | K07897 | Matching products |
UniProt ID : | P51149 | Matching products |
Gene ID | GeneID 7879 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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