Porcine TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit

Porcine TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit is a high quality kit for research use only from Assay Genie. The Porcine TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit comes in a 96 Assays format and reacts against Porcine samples. We ship this kit on Gel Pack and kits should be stored at 2-8°C Protein Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity) , The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells [The Uniprot Consortium]