Mouse OPA1 (Optic Atrophy 1) ELISA Kit

ELISA Type: Sandwich ELISA, Double Antibody. Detection Range: 31.25-2000µg/mL. Sensitivity: 18.75µg/mL. Sample Types: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples. Protein function: Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:11847212, PubMed:16839884, PubMed:16839885, PubMed:24055366, PubMed:24616225, PubMed:24627489, PubMed:25298396, PubMed:26785494, PubMed:28636943, PubMed:28746876, PubMed:33200421, PubMed:33237841, PubMed:36171294, PubMed:38225406). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form, L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form, S- OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:24703695, PubMed:28636943, PubMed:33237841). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:33237841). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S- OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:33200421). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (PubMed:33200421, PubMed:38225406). Involved in remodeling cristae and the release of cytochrome c during apoptosis (PubMed:16839884). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (PubMed:16839884, PubMed:16839885). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (PubMed:36171294). Its role in mitochondrial morphology is required for mitochondrial genome maintenance. [The UniProt Consortium]