Mouse MMP14 (Matrix Metalloproteinase-14) ELISA kit

ELISA Type: Sandwich ELISA, Double Antibody. Detection Range: 15.625-1000µg/mL. Sensitivity: 9.375µg/mL. Sample Types: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples. Protein function: Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:10520996, PubMed:10737763). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996, PubMed:10737763). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:10737763). Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851). [The UniProt Consortium]