Mouse Fads2 (Fatty acid desaturase 2) ELISA Kit (MOFI01447)

Mouse Fads2 (Fatty acid desaturase 2) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Mouse Fads2 (Fatty acid desaturase 2) in serum, plasma & cell culture supernatant samples. The Mouse Fads2 (Fatty acid desaturase 2) ELISA Kit accurately measures natural Mouse Fads2 (Fatty acid desaturase 2) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Mouse Fads2 (Fatty acid desaturase 2) peptide. Protein function: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:9867867). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates. [The UniProt Consortium]