Mouse DKK3(Dickkopf Related Protein 3) ELISA Kit

Detection Range: 15.63-1000 pg/mL. Test Principle: Colorimetric method,ELISA,Sandwich. Sensitivity: 9.38 pg/mL. Protein function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) [The UniProt Consortium]