Mouse Dickkopf-related protein 1 (DKK1) ELISA kit

Sample Types: serum, plasma, tissue homogenates Detection Range: 78.125 pg/mL-5000 pg/mL Sensitivity: 13.127 pg/mL Assay Principle: quantitative Measurement: SandwichAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development, attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822). [The UniProt Consortium]