monocyte chemotactic protein 1/monocyte chemotactic and activating factor, MCP-1/MCAF (rat) ELISA Ki

Sample Types: serum, plasma, cell culture supernates, tissue homogenates. Detection Range: 3.9 pg/mL-250 pg/mL. Sensitivity: 1.95 pg/mL. Assay Principle: quantitative. Measurement: Sandwich. Assay Time: 1-5h. Sample Volume: 50-100ul. Detection Wavelength: 450 nm. Protein function: Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. [The UniProt Consortium]