Mini Sample Human IgE (Immunoglobulin E) ELISA Kit

IgE, Immunoglobulin E (Ige), is a kind of immune globulin, mainly involved in allergic reactions and parasitic infections and other immune reactions. IgE can produce allergic reactions, such as asthma and allergic rhinitis, when the body is exposed to certain antigens. Measurement of IgE levels can help diagnose and monitor the extent of these allergic reactions and the efficacy of treatment.Gene AliasIGHEGene ID3497Uniport IDP01854Protein AliasIGHEResearch AreaImmunology Protein function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). [The UniProt Consortium]