Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) ELISA Kit (HUFI06160)

Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) in serum, plasma & cell culture supernatant samples. The Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) ELISA Kit accurately measures natural Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) peptide. Protein function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. [The UniProt Consortium]