Human TAB1/TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 ELISA Kit

Human TAB1/TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-HUFI01904.96 96 assays -

9 - 20 business days*

698.00€
 
ELISA Type: Sandwich. Detection Range: 0.313-20µg/mL. Sensitivity: 0.188µg/mL. Sample Types:... more
Product information "Human TAB1/TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 ELISA Kit"
ELISA Type: Sandwich. Detection Range: 0.313-20µg/mL. Sensitivity: 0.188µg/mL. Sample Types: Serum, Plasma. Protein function: Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). [The UniProt Consortium]
Keywords: TAB1, MAP3K7IP1, TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Supplier: Assay Genie
Supplier-Nr: HUFI01904

Properties

Application: Sandwich ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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