Human SHARPIN (Sharpin) ELISA Kit (HUFI06539)

Human SHARPIN (Sharpin) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human SHARPIN (Sharpin) in serum, plasma & cell culture supernatant samples. The Human SHARPIN (Sharpin) ELISA Kit accurately measures natural Human SHARPIN (Sharpin) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human SHARPIN (Sharpin) peptide. Protein function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. [The UniProt Consortium]