Human SASH1 (SAM and SH3 domain-containing protein 1) ELISA Kit (HUFI08090)

Human SASH1 (SAM and SH3 domain-containing protein 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human SASH1 (SAM and SH3 domain-containing protein 1) in serum, plasma & cell culture supernatant samples. The Human SASH1 (SAM and SH3 domain-containing protein 1) ELISA Kit accurately measures natural Human SASH1 (SAM and SH3 domain-containing protein 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human SASH1 (SAM and SH3 domain-containing protein 1) peptide. Protein function: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). [The UniProt Consortium]