Human MAML1 (Mastermind-like protein 1) ELISA Kit (HUFI03513)

Human MAML1 (Mastermind-like protein 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human MAML1 (Mastermind-like protein 1) in serum, plasma & cell culture supernatant samples. The Human MAML1 (Mastermind-like protein 1) ELISA Kit accurately measures natural Human MAML1 (Mastermind-like protein 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human MAML1 (Mastermind-like protein 1) peptide. Protein function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. [The UniProt Consortium]