Human GPR124 (G Protein Coupled Receptor 124) ELISA Kit (HUFI03421)

Human GPR124  (G Protein Coupled Receptor 124) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human GPR124  (G Protein Coupled Receptor 124) in serum, plasma & cell culture supernatant samples. The Human GPR124  (G Protein Coupled Receptor 124) ELISA Kit accurately measures natural Human GPR124  (G Protein Coupled Receptor 124) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human GPR124  (G Protein Coupled Receptor 124) peptide. Protein function: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). [The UniProt Consortium]