Product information "Human GDF11 (Growth Differentiation Factor 11) ELISA Kit"
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of GDF11 in serum, plasma and other biological fluids. Detection Range: 15.63--1000pg/mL. Sensitivity: 9.38pg/mL. Protein function: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). [The UniProt Consortium]
GDF11, GDF-11, BMP-11, Bone morphogenetic protein 11, Growth/differentiation factor 11