Human FGF acidic ELISA Kit

Human FGF acidic ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG81255.96 96 wells -

6 - 14 business days*

774.00€
 
Protein function: Plays an important role in the regulation of cell survival, cell division,... more
Product information "Human FGF acidic ELISA Kit"
Protein function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). [The UniProt Consortium]
Keywords: ECGF, aFGF, FGFA, FGF1, FGF-1, HBGF-1, Fibroblast growth factor 1, Endothelial cell growth factor, Heparin-binding growth factor 1, Acidic fibroblast growth factor
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG81255

Properties

Application: ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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