Human FAM19A5 ELISA Kit (HUFI04339)

Human FAM19A5 ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human FAM19A5 in serum, plasma & cell culture supernatant samples. The Human FAM19A5 ELISA Kit accurately measures natural Human FAM19A5 levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human FAM19A5 peptide. Protein function: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries. [The UniProt Consortium]