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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG82404.96 | 96 wells | - |
6 - 14 business days* |
1,151.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Selectively promotes the survival of dopaminergic neurons of the ventral... more
Product information "Human ARMET ELISA Kit"
Protein function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057). [The UniProt Consortium]
| Keywords: | MANF, ARMET, Protein ARMET, Arginine-rich protein, Mesencephalic astrocyte-derived neurotrophic factor |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG82404 |
Properties
| Application: | ELISA |
| Species reactivity: | human |
| Format: | Solid Phase |
Database Information
| KEGG ID : | K22556 | Matching products |
| UniProt ID : | P55145 | Matching products |
| Gene ID : | GeneID 7873 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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