Human Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) ELISA kit

Sample Types: serum, plasma, tissue homogenates, cell lysates Detection Range: 0.625 ng/mL-40 ng/mL Sensitivity: 0.156 ng/mL Assay Principle: quantitative Measurement: SandwichAssay Time: 1-5h Sample Volume: 50-100ulDetection Wavelength: 450 nmProtein function: Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro). [The UniProt Consortium]