8-Isoprostane ELISA Kit

8-Isoprostane ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay516351-96S 96 so-wells (96 solid wells) -

6 - 10 business days*

Cay516351-96 96 st-wells (96 strip wells) -

6 - 10 business days*

Cay516351-480S 480 so-wells (480 solid wells) -

6 - 10 business days*

Cay516351-480 480 st-wells (480 strip wells) -

6 - 10 business days*

The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random... more
Product information "8-Isoprostane ELISA Kit"
The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. Isoprostanes appear as artifacts in tissue and plasma samples which have undergone oxidative degradation during prolonged or improper storage. They also appear in the plasma and urine under normal conditions and are elevated by oxidative stress. At least one of the isoprostanes, 8-isoprostane (8-epi PGF2alpha), has been shown to have biological activity. It is a potent pulmonary and renal vasoconstrictor and has been implicated as a causative mediator of hepatorenal syndrome and pulmonary oxygen toxicity. 8-Isoprostane has been proposed as a marker of antioxidant deficiency and oxidative stress and elevated levels have been found in heavy smokers. 8-Isoprostane levels are also a relative indicator of sample integrity for lipid-containing samples such as serum, plasma, and whole cell preparations. Plasma from healthy volunteers contains modest amounts of 8-isoprostane (40-100 pg/ml) that increase with the age of the test subject. Normal human urinary levels range from 10-50 ng/mmol creatinine, which is an order of magnitude higher than many enzymatically derived eicosanoids. Synonyms: iPF2alpha-III, 8-Isoprostane EIA Kit, 8-epi Prostaglandin F2alpha, 8-iso Prostaglandin F2alpha. Assay Range: 0.8-500 pg/ml. Sensitivity: 80% B/B0: 3 pg/ml. Mid-point: 50% B/B0: 7-20 pg/ml. Cross Reactivity: (8-Isoprostane) 100%, (8-iso Prostaglandin F2alpha ethanolamide) 100%, (8-iso Prostaglandin F3alpha) 20.6%, (2,3-dinor-8-iso Prostaglandin F2alpha) 4.00%, (8-iso Prostaglandin E2) 1.84%, (2,3-dinor-8-iso Prostaglandin F1alpha) 1.7%, (8-iso Prostaglandin E1) 1.56%, (Prostaglandin F1alpha) 0.71%, (Prostaglandin F3alpha) 0.66%, (Prostaglandin E1) 0.39%, (Prostaglandin D2) 0.16%, (6-keto Prostaglandin F1alpha) 0.14%, (Prostaglandin F2alpha) 0.14%, (2,3-dinor-6-keto Prostaglandin F1alpha) 0.09%, (8-iso Prostaglandin F1beta) 0.08%, (Thromboxane B2) 0.08%, (11-dehydro Thromboxane B2) 0.07%, (11beta-Prostaglandin F2alpha) 0.03%, (Prostaglandin E2) 0.02%, (8-iso-15(R)-Prostaglandin F2alpha) 0.02%, (8,12-epi iPF2alpha-III) <0.01%, (iPF2alpha-VI) <0.01%, (8,12-epi iPF2alpha-VI) <0.01%, (tetranor-PGEM) <0.01%, (tetranor-PGFM) <0.01%, (13,14-dihydro-15-keto Prostaglandin F2alpha) <0.01%. Origin: Animal/Bovine, Animal/Eel, Animal/Mouse, Animal/Rabbit.
Keywords: 8-epi Prostaglandin F2alpha, 8-iso Prostaglandin F2alpha, 8-Isoprostane EIA Kit, iPF2alpha-III
Supplier: Cayman Chemical
Supplier-Nr: 516351


Application: ELISA
Format: Solid Phase

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H317, H319
P Phrases: P261, P264, P272, P280, P302+352, P305+351+338, P321, P333+313, P337+313, P362+364, P501
Our products are for laboratory research use only: Not for administration to humans!
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