Cathepsin C (DPPI) Inhibitor Screening Assay Kit (Mouse)

The Cathepsin C (DPPI) Inhibitor Screening Assay Kit (Mouse) is designed to measure the protease activity of Cathepsin C, also known as DPPI (dipeptidyl peptidase I) for screening and profiling applications. This kit comes in a convenient 96-well format, with enough recombinant mouse cathepsin C (procathepsin C), substrate and buffer for 100 reactions. Cathepsin C, also known as DPPI (dipeptidyl peptidase I), is a lysosomal aspartic protease with dipeptidylpeptidase activity over a broad range of substrates. It is mostly found in lysosomes, where it degrades intra- and extra-cellular proteins, regulates cell death, and plays a role in inflammation. It can activate proteins such as elastase, and granzyme A and B. It is found at high levels in several cancer types, and it has been linked to an increase in metastasis and angiogenesis. Its role in cancer has made it an attractive target in oncology, with active development of specific, membrane permeable inhibitors.