Cathepsin C (DPPI) Inhibitor Screening Assay Kit

The Cathepsin C (DDPI) Screening Assay Kit is a fluorogenic assay designed to measure the protease activity of human Cathepsin C, also known as DPPI (dipeptidyl peptidase I) for screening and profiling applications. This kit comes in a convenient 96-well format, with enough recombinant human cathepsin C (amino acids 25-463, procathepsin C), Cathepsin L (amino acids 18-333) for activation, substrate and buffer for 100 reactions. Cathepsin C, also known as DPPI (dipeptidyl peptidase I), is a lysosomal aspartic protease with dipeptidylpeptidase activity over a broad range of substrates. It is mostly found in the lysosomes, where it degrades intra- and extra-cellular proteins, regulates cell death, and plays a role in inflammation. It can activate proteins such as elastase, and granzyme A and B. It is found at high levels in several types of cancer, and it has been linked to an increase in metastasis and angiogenesis. Its role in cancer has made it an attractive target in oncology, with active development of specific, membrane permeable inhibitors.