Anti-IgD Heavy Chain for IHC / IGHD, clone MSVA-701R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Immunoglobulin D (IgD) is an antibody isotype expressed primarily on the surface of mature naive B lymphocytes and plays an important role in B cell activation and immune regulation. The IgD heavy chain is encoded by the IGHD gene and forms part of the B cell receptor complex together with immunoglobulin light chains. IgD Heavy Chain Antibody for IHC is used to detect this immunoglobulin component in tissue sections, enabling visualization of IgD-expressing B cell populations within lymphoid organs and immune infiltrates.IgD belongs to the immunoglobulin superfamily and is structurally composed of two delta heavy chains paired with two light chains, forming a monomeric antibody molecule. Membrane-bound IgD functions as an antigen receptor on mature B cells where it cooperates with surface IgM to regulate B cell activation, antigen recognition, and signaling. Engagement of the B cell receptor containing IgD can initiate intracellular signaling cascades that influence lymphocyte survival, differentiation, and antibody production.In normal human tissues, IgD expression is most prominently detected in B lymphocytes within secondary lymphoid organs such as tonsil, lymph node, and spleen. Within lymphoid follicles, IgD positive B cells are typically enriched in mantle zone regions surrounding germinal centers. This characteristic distribution makes IgD immunohistochemical staining a useful tool for evaluating lymphoid tissue architecture and identifying specific B cell subsets within reactive or neoplastic lymphoid proliferations.IgD heavy chain antibody detection can also provide diagnostic information in hematopathology. Immunohistochemical staining for IgD may help characterize B cell lineage and maturation stage in certain lymphoid malignancies or plasma cell disorders. In research contexts, detection of IgD contributes to studies of B cell biology, antigen receptor signaling, and the organization of immune cell populations within lymphoid tissues.A recombinant rabbit monoclonal IgD Heavy Chain Antibody for IHC such as clone MSVA-701R enables sensitive detection of IgD expressing cells in formalin-fixed paraffin-embedded tissue sections. Immunohistochemistry staining typically demonstrates membranous and cytoplasmic localization in B lymphocytes consistent with the distribution of IgD as part of the B cell receptor complex.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.