Anti-Human SP3 Antibody Pair

Product Description: Transcription factor Sp3 (SP3) is a member of the Sp family of transcription factors, characterized by its ability to bind to GC-rich promoter regions and regulate gene expression. SP3 contains multiple zinc finger domains that facilitate its interaction with DNA and other proteins, enabling it to either activate or repress target genes depending on the cellular context. This bifunctional nature allows SP3 to play a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of SP3 expression or function has been implicated in several diseases. For instance, altered levels of SP3 have been associated with tumor progression in breast and colorectal cancers, where it may influence the expression of oncogenes and tumor suppressor genes. Additionally, SP3's interactions with other transcription factors and co-regulators can affect inflammatory responses and metabolic pathways. Protein Function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping [The Uniprot Consortium]