Anti-Human RASA1 Antibody Pair

Product Description: RAS p21 protein activator 1 (RASA1), also known as p120-RasGAP, is a cytoplasmic protein that functions as a key negative regulator of the RAS/MAPK signaling pathway, which is crucial for controlling cell proliferation, differentiation, and movement. Structurally, RASA1 contains several domains, including SH2, SH3, C2A, C2B, GAP, and PH, enabling it to interact with various signaling molecules and enhance the intrinsic GTPase activity of RAS proteins, thereby converting active RAS-GTP to its inactive GDP-bound form and suppressing RAS signaling. RASA1 is also involved in physiological processes such as angiogenesis, apoptosis, and the development of the vascular system, and its activity is regulated by intracellular calcium levels and membrane association. Pathogenic mutations or epigenetic inactivation of RASA1 are linked to vascular anomalies, such as capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in the development of various cancers due to dysregulated RAS signaling. Protein Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21, this stimulation may be further increased in the presence of NCK1 [The Uniprot Consortium]