Anti-Human NELL1 Antibody Pair

Product Description: Neural EGFL like 1 (NELL1) is a secreted protein characterized by its epidermal growth factor (EGF)-like repeats, playing a pivotal role in cellular growth and differentiation, particularly in osteogenesis. Functionally, NELL1 interacts with integrin beta1, activating the Wnt/beta-catenin signaling pathway, which promotes osteoblast differentiation and inhibits osteoclast activity. NELL1 is crucial for skeletal ossification, as its overexpression can lead to craniosynostosis, a condition where skull bones fuse prematurely, while its deficiency is linked to age-related osteoporosis, marked by decreased bone density and increased fragility. Beyond skeletal implications, NELL1 has been identified as a target antigen in membranous nephropathy (MN). Protein Function: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization [The Uniprot Consortium]