Anti-Human IL37 Antibody Pair

Product Description: Interleukin-37 (IL-37) is an anti-inflammatory cytokine belonging to the IL-1 family, comprising five isoforms (IL-37a-e), with IL-37b being the most extensively studied. This protein plays a crucial role in modulating immune responses by inhibiting the production of pro-inflammatory cytokines, thereby protecting tissues from excessive inflammation and damage. Its mechanism involves binding to the IL-18 receptor and recruiting the co-receptor IL-1R8, which activates anti-inflammatory signaling pathways. Notably, IL-37 can also suppress the activation of the inflammasome, further contributing to its protective effects against inflammatory conditions. IL-37 is expressed in various tissues and its levels are notably elevated in inflammatory diseases such as systemic lupus erythematosus, colitis, asthma, and certain cancers. Protein Function: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation [The Uniprot Consortium]